Synthesis of a C1–C11 fragment of Zincophorin using planar chiral, neutral π-allyl iron complexes?

Organic & Biomolecular Chemistry Pub Date: 2013-06-19 DOI: 10.1039/C3OB40894A

Abstract

A key step in the synthesis of a C1–C11 fragment of the ionophore antibiotic Zincophorin involves the addition of an α-alkoxyalkylcopper(I) reagent to a planar chiral, neutral π-allyl iron complex. The key allylic alkylation reaction is highly regio- and stereoselective with addition taking place at the γ-position anti to the metal centre.

Graphical abstract: Synthesis of a C1–C11 fragment of Zincophorin using planar chiral, neutral π-allyl iron complexes
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