Visible-light-induced photocatalyst-free C-3 functionalization of indoles with diethyl bromomalonate?
Green Chemistry Pub Date: 2020-03-19 DOI: 10.1039/D0GC00292E
Abstract
A visible-light induced green and efficient method is developed for the synthesis of α-indolyl diethyl malonates. The reaction proceeds without any photocatalysts or ligands in a green solvent in a short time. Moreover, the reaction mechanism has been clearly studied by control experiments, spectrophotometric studies and density functional theory (DFT) calculations. The results showed that the photocatalyst-free transformation may proceed via an XB-promoted radical process. The EDA complex formation of diethyl bromomalonate with a base is the main reason for the reaction initiation.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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