Sulfonamide-directed gold-catalyzed [2+2+2]-cycloadditions of nitriles with two discrete ynamides to construct 2,4-diaminopyridine cores?
Chemical Communications Pub Date: 2016-01-15 DOI: 10.1039/C5CC09688J
Abstract
Gold-catalyzed [2+2+2]-cycloadditions of two discrete ynamides and one nitrile afford 2,4-diaminopyridine derivatives that are not readily prepared from typical low-valent-metal catalysts. Our mechanistic analysis reveals that the reaction chemoselectivity is controlled by the types of sulfonamides of ynamides.
![Graphical abstract: Sulfonamide-directed gold-catalyzed [2+2+2]-cycloadditions of nitriles with two discrete ynamides to construct 2,4-diaminopyridine cores](http://scimg.chem960.com/usr/1/C5CC09688J.jpg)
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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