Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery?
Journal of Materials Chemistry C Pub Date: 2016-02-19 DOI: 10.1039/C6TC00122J
Abstract
Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 ?C to 65 ?C.
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Journal Name：Journal of Materials Chemistry C
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CAS no.: 89640-58-4
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