Unorthodox cascade reaction of arynes and N-nitrosamides leading to indazole scaffolds?
Chemical Communications Pub Date: 2021-12-20 DOI: 10.1039/D1CC05655G
Abstract
An unusual cascade annulation of arynes with N-alkyl-N-nitrosamides is developed by leveraging aryne σ-insertion and C(sp3)–H bond functionalization strategies under transition-metal-free conditions at ambient temperature, offering functionalized indazoles in high yields and regioselectivity. The protocol is scalable and exhibits a broad substrate scope. The reaction mechanism is also studied with DFT calculations.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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