Synthesis of α-sulfenyl monoketones via a metal-free oxidative cross dehydrogenative coupling (CDC) reaction?
Organic & Biomolecular Chemistry Pub Date: 2016-07-15 DOI: 10.1039/C6OB01243D
Abstract
α-Sulfenyl ketones are potential precursors which find a variety of applications in organic synthesis. Their typical synthesis requires pre-functionalized starting materials and two to three step synthetic sequences. In addition, the selective pre-functionalization of unsymmetrical ketones is a challenge, which limits the synthesis of the desired sulfenylated ketones. To overcome these disadvantages, a metal-free, convenient one-step strategy for synthesizing α-sulfenyl ketones at ambient temperature via a cross-dehydrogenative coupling (CDC) strategy has been developed with a broad substrate scope. Therefore, this CDC strategy for C–S bond formation is attractive and may find wide applications in organic synthesis.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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