Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis?

Chemical Communications Pub Date: 2013-07-04 DOI: 10.1039/C3CC42594K

Abstract

OvoA is an iron(II) dependent sulfoxide synthase which catalyzes the first step in ovothiol A biosynthesis. This enzyme sulphurizes the C5 position of the imidazole side chain of L-histidine. We report the substrate specificity profile of this catalyst and present data which indicate that OvoA catalysis follows an thiol-ene type mechanism.

Graphical abstract: Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis
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