Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols?
Organic Chemistry Frontiers Pub Date: 2015-04-20 DOI: 10.1039/C5QO00060B
Abstract
A convenient and efficient synthetic method for the construction of morpholine and piperazine derivatives in moderate to good yields was established. The reaction proceeds smoothly with 1.0 mol% gold catalyst loading. A plausible mechanism involving the cascade cyclization and isomerizations to produce the six-membered ring was proposed and supported by deuterium labeling experiments.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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