Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology

Organic & Biomolecular Chemistry Pub Date: 2009-12-03 DOI: 10.1039/B918488K

Abstract

Cholesterol-derived hormones, the dafachronic acids, play a major role in controlling the life cycle and initiating dauer larva formation of the nematode Caenorhabditis elegans. This Perspective describes recent progress in the synthesis of these steroid hormones and their biological function.

Graphical abstract: Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology
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