Synthesis of 4-trifluoromethyl 2-pyrones and pyridones through the Br?nsted base-catalyzed Pechmann-type reaction with cyclic 1,3-diones?
Organic & Biomolecular Chemistry Pub Date: 2018-11-27 DOI: 10.1039/C8OB02701C
Abstract
An efficient method for the synthesis of 4-trifluoromethyl 2-pyrones through the Br?nsted base-catalyzed Pechmann-type reaction of cyclic 1,3-diones with ethyl 4,4,4-trifluoroacetoacetate is described. In the presence of 2-dimethylamino pyridine (2-DMAP) as a catalyst, the resulting 4-trifluoromethyl 2-pyrones are formed in good to excellent yields. Additionally, the reaction also provides 4-trifluoromethyl 2-pyridones by using the easily available NH4OAc as a source of NH3.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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