Synthesis of 18O-labelled alcohols from unlabelled alcohols?
Chemical Communications Pub Date: 2020-05-19 DOI: 10.1039/D0CC02855J
Abstract
The synthesis of primary, secondary and tertiary 18O-enriched alcohols from readily available 16O-alcohols via a Mitsunobu esterification and hydrolysis is described. The method is further exemplified in the labelling of the active pharmaceutical ingredient, dropropizine and is shown to be tolerant of modern, separation friendly Mitsunobu reagents.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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