Transition-metal-free N-difluoromethylation of hydrazones with TMSCF2Br as the difluoromethylation reagent?
Organic Chemistry Frontiers Pub Date: 2019-05-27 DOI: 10.1039/C9QO00506D
Abstract
Herein a novel and practical protocol to synthesize a series of N-difluoromethyl hydrazones via base-promoted N-difluoromethylation is reported. With hydrazones as chain substrates containing N–N bonds and TMSCF2Br as the difluoromethylation reagent, the reaction delivers N-difluoromethyl hydrazones in good yields, which exhibit good functional group tolerance and stereoselectivity.
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Journal Name：Organic Chemistry Frontiers
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