Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source?
Chemical Communications Pub Date: 2019-06-10 DOI: 10.1039/C9CC03534F
Abstract
An efficient transition metal-free annulation of amidine with ethyl bromodifluoroacetate to access 2,4-disubstituted-1,3,5-triazines is firstly presented. The desired symmetric and unsymmetric 2,4-disubstituted-1,3,5-triazines were obtained in decent yields via multiple C–N bond formation, in which ethyl bromodifluoroacetate is harnessed as a unique C1 synthon via quadruple cleavage. This reaction is transition metal-free, oxidant-free and simple in operation, and only lowly toxic inorganic wastes are generated.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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