Transition metal catalyzed C–H bond activation by exo-metallacycle intermediates
Chemical Communications Pub Date: 2021-09-29 DOI: 10.1039/D1CC05042G
Abstract
exo-Metallacycles have become the key reaction intermediates in activating various remote C(sp2)–H and C(sp3)–H bonds in the past decade and aided in achieving unusual site-selectivity. Various novel exo-chelating auxiliaries have assisted metals to reach desired remote C–H bonds of different alcohol and amine-derived substrates. As a result, a wide range of organic transformations of C–H bonds like halogenation, acetoxylation, amidation, sulfonylation, olefination, acylation, arylation, etc. were accessible using the exo-metallacycle strategy. In this review, we have summarized the developments in C–H bond activation via four-, five-, six-, seven- and eight-membered exo-metallacycles and the key reaction intermediates, including the mechanistic aspects, are discussed concisely.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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