Synthesis and structural reconfirmation of bacillamide B?
Organic & Biomolecular Chemistry Pub Date: 2015-02-25 DOI: 10.1039/C5OB00093A
Abstract
A concise total synthesis of the natural product bacillamide B was accomplished in 30% overall yield starting from L-cystine. The key step was a one-pot four-step process of thiazoline formation via a cascade disulfide cleavage/thiocarbonylation/Staudinger reduction/aza-Wittig reaction using β-azido disulfide and carboxylic acid as substrates. The absolute configuration of the natural bacillamide B was reconfirmed to be S and the specific optical rotation was revised to (?).
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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