Visible-light-induced C(sp3)–H functionalizations of piperidines to 3,3-dichloro-2-hydroxy-piperidines with N-chlorosuccinimide?
Organic & Biomolecular Chemistry Pub Date: 2021-06-18 DOI: 10.1039/D1OB00868D
Abstract
A visible-light-induced synthesis of 3,3-dichloro-2-hydroxy-piperidines via site-selective functionalizations of C(sp3)?H in N-substituted piperidines using easily available N-chlorosuccinimide as chlorine source was developed. Mechanistic investigations suggest that chlorine radical is involved in this transformation.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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