Straightforward synthesis of gem-phosphonate-phosphate containing compounds via one-pot reaction of thioesters with diethyl phosphite?

Chemical Communications Pub Date: 2004-04-01 DOI: 10.1039/B401079E

Abstract

A convenient straightforward, three step, one-pot reaction of diethyl phosphite with thioesters in the presence of catalytic amounts of potassium tert-butoxide in toluene or DMF as solvent provided various phosphonate-phosphate containing compounds in excellent yields.

Graphical abstract: Straightforward synthesis of gem-phosphonate-phosphate containing compounds via one-pot reaction of thioesters with diethyl phosphite
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