Spectrophotometric method for determination of chlorpheniramine maleate in pharmaceutical preparations in the presence of codeine phosphate and ephedrine hydrochloride
ANALYSTANALYST Pub Date: DOI: 10.1039/AN9800500353
Abstract
A simple spectrophotometric method has been developed for the assay of chlorpheniramine maleate in raw materials and in pharmaceutical preparations. The method depends on the reaction of chlorpheniramine maleate with aniline in the presence of cyanogen bromide resulting in an intense yellow colour that has an absorption maximum at 482 nm at pH 7.0 and obeys Beer's law in the concentration range 50–175 μg ml–1. The proposed method can be used for the determination of chlorpheniramine maleate in tablets, syrups and injections in the presence of codeine phosphate and ephedrine hydrochloride. The effect of pH and time on the formation of the derivative was also investigated.
Recommended Literature
- [1] Empowering microfluidics by micro-3D printing and solution-based mineral coating? Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun ZhangSoft Matter, 2020,16, 6841-6849 10.1039/D0SM00958J
- [2] Dissociation of large gaseous serine clusters produces abundant protonated serine octamer Jacob S. Jordan,Evan R. WilliamsAnalyst, 2021,146, 2617-2625 10.1039/D1AN00273B
- [3] Fate of single walled carbon nanotubes in wetland ecosystems? Joseph H. Bisesi,Tara Sabo-AttwoodEnviron. Sci.: Nano, 2014,1, 574-583 10.1039/C4EN00063C
- [4] Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries? Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde WangJ. Mater. Chem. A, 2018,6, 516-526 10.1039/C7TA08423D
- [5] Excellent lithium ion storage property of porous MnCo2O4 nanorods? Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen FangRSC Adv., 2016,6, 23074-23084 10.1039/C5RA26176G
- [6] Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings Analyst, 1996,121, 785-788 10.1039/AN9962100785
- [7] Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung WongJ. Mater. Chem. C, 2015,3, 12322-12327 10.1039/C5TC03165F
- [8] Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization. LarsBanko,AlfredLudwig 10.1021/acscombsci.0c00057
- [9] Emergence of microfluidic wearable technologies Joo Chuan Yeo,KenryLab Chip, 2016,16, 4082-4090 10.1039/C6LC00926C
- [10] Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications Partha Laskar,Christine DufèsNanoscale Adv., 2021,3, 6007-6026 10.1039/D1NA00536G
Journal Name：ANALYSTANALYST
research_products
-
CAS no.: 89640-58-4
![N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide](https://ossimg.kuujia.com/scimg/1444500/1444113-98-7x500.png)
![1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol](https://ossimg.kuujia.com/scimg/1271000/1270529-38-8x500.png)
![2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid](https://ossimg.kuujia.com/scimg/2138500/2138166-62-6x500.png)
![2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide](https://ossimg.kuujia.com/scimg/2034500/2034271-14-0x500.png)