Synthesis and evaluation of N-alkylated analogues of aza-galacto-fagomine – potential pharmacological chaperones for Krabbe disease?
Organic & Biomolecular Chemistry Pub Date: 2016-08-08 DOI: 10.1039/C6OB01309K
Abstract
Seven novel alkylated or acylated analogues of hexahydropyridazine aza-galacto-fagomine (AGF) was prepared and studied as glycosidase inhibitors with the aim of increasing inhibitory potency and selectivity. The enzyme galactocerebrosidase, implicated in Krabbe disease, was found to be potently inhibited by n-butyl N2-alkylated AGF.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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