Tin(ii) chloride assisted synthesis of N-protected γ-amino β-keto esters through semipinacol rearrangement?

Organic & Biomolecular Chemistry Pub Date: 2010-08-24 DOI: 10.1039/C0OB00199F

Abstract

A facile synthetic route for the preparation of N-protected γ-amino β-keto esters from amino aldehydes and ethyl diazoacetate is described. The two component coupling is facilitated by tin(II) chloride followed by semipinacol rearrangement leading to the product in quantitative yield. The reaction is mild, instantaneous and compatible with Boc-, Fmoc- and Cbz-amino protecting groups.

Graphical abstract: Tin(ii) chloride assisted synthesis of N-protected γ-amino β-keto esters through semipinacol rearrangement
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