Synthesis and 18F-radiolabeling of thymidine AMBF3 conjugates?
RSC Medicinal Chemistry Pub Date: 2020-04-23 DOI: 10.1039/D0MD00054J
Abstract
In pursuit of 18F-labeled nucleosides for positron emission tomography (PET) imaging, we report on the chemical and radiochemical synthesis of two thymidine (dT) analogs, dT-C5-AMBF3 and dT-N3-AMBF3, that are radiofluorinated by isotope exchange (IEX) and studied as PET imaging agents in mice with tumor xenografts. dT-C5-AMBF3 shows preferential, and tumor-specific, uptake over dT-N3-AMBF3. This work provides a new synthetic method in order to access new nucleoside tracers for PET imaging.
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Journal Name：RSC Medicinal Chemistry
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CAS no.: 89640-58-4
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