SNAr reaction in aqueous medium in the presence of mixed organic and inorganic bases?
RSC Advances Pub Date: 2015-03-26 DOI: 10.1039/C5RA03510D
Abstract
N-Arylation of amines with fluorobenzonitriles in aqueous medium is described. A mixture of N,N-diisopropylethyl amine and Na2CO3 (1?:?1) is found to achieve maximum conversion by refluxing for 3 hours in water. The product can be easily isolated by solvent extraction.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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