Solvent based selectivity in the synthesis of di(2-aryl-1H-3-indolyl) sulfides and 1-aryl-2-[(2-aryl-1H-3-indolyl)sulfanyl]-1-ethanones?

RSC Advances Pub Date: 2011-12-15 DOI: 10.1039/C1RA00878A

Abstract

The commendable product selectivity exhibited by the solvents during the reaction of 2-[(2-oxo-2-arylethyl)sulfanyl]-1-aryl-1-ethanones with phenylhydrazine hydrochloride yielding exclusively 1-aryl-2-[(2-aryl-1H-3-indolyl)sulfanyl]-1-ethanones in THF and di(2-aryl-1H-3-indolyl) sulfides in ethanol is described.

Graphical abstract: Solvent based selectivity in the synthesis of di(2-aryl-1H-3-indolyl) sulfides and 1-aryl-2-[(2-aryl-1H-3-indolyl)sulfanyl]-1-ethanones
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