Solid-phase synthesis of peptide selenoesters via a side-chain anchoring strategy?

Chemical Communications Pub Date: 2017-04-24 DOI: 10.1039/C7CC00823F

Abstract

Peptide selenoesters have recently emerged as key building blocks for the ligation-based assembly of large polypeptides and proteins. Herein, we report an efficient solid-phase method for the high yielding and epimerisation-free synthesis of peptide selenoesters using a side-chain immobilisation strategy.

Graphical abstract: Solid-phase synthesis of peptide selenoesters via a side-chain anchoring strategy
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