Silver-mediated radical coupling reaction of isocyanides and alcohols/phenols in the presence of water: unprecedented hydration and radical coupling reaction sequence?
Organic & Biomolecular Chemistry Pub Date: 2017-01-17 DOI: 10.1039/C7OB00019G
Abstract
The radical coupling of isocyanides and alcohols/phenols promoted by silver in the presence of water is reported for the first time, which led to the formation of diverse carbamates. In contrast to the well-known 1,1-addition to form imidoyl radicals, a novel reaction mechanism, involving sequential hydration of isocyanides and coupling with alkoxyl/phenoxyl radicals, is disclosed by combining experimental and theoretical studies.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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