Silver-mediated oxidative 1,2-alkylesterification of styrenes with nitriles and acids via C(sp3)–H functionalization?

Chemical Communications Pub Date: 2019-10-02 DOI: 10.1039/C9CC06437K

Abstract

A new silver-mediated 1,2-alkylesterification of alkenes with nitriles and acids promoted by a catalytic amount of nickel catalyst for producing acyloxylated nitriles has been developed via a C(sp3)–H functionalization process. By employing the NiI2 and Ag2CO3 catalytic systems, the method features broad substrate scope with respect to carboxylic acids, including linear alkyl acids, cyclic acids, aryl acids and amino acids.

Graphical abstract: Silver-mediated oxidative 1,2-alkylesterification of styrenes with nitriles and acids via C(sp3)–H functionalization
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