Silver-catalyzed intermolecular amination of fluoroarenes?
Organic & Biomolecular Chemistry Pub Date: 2018-08-15 DOI: 10.1039/C8OB01749B
Abstract
A novel highly selective Ag-catalyzed intermolecular amination of fluoroarenes has been developed. This transformation starts from readily available 4-carbonyl fluorobenzene and NaN3 or other nitrogen-source, via amination followed by C–F bond cleavage, thus affording the desired 4-carbonyl arylamine products under mild conditions. The reaction is accelerated using a small amount of water. This pathway is distinct from a previously reported radical amination reaction.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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