5-Membered N-heterocyclic compounds by dimethyl carbonate chemistry?

Green Chemistry Pub Date: 2011-10-18 DOI: 10.1039/C1GC15698E

Abstract

Aliphatic and aromatic 1,4-bifunctional compounds bearing a primary alcoholic function and an amine can be efficiently cyclised with dimethyl carbonates in the presence of a base to achieve 5-membered N-heterocyclic compounds. This novel synthetic pathway is quantitative, one-pot and green as it does not involve the use of chlorine solvents or reagent.

Graphical abstract: 5-Membered N-heterocyclic compounds by dimethyl carbonate chemistry
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