Adaptive and automated system-optimization for heterogeneous flow-hydrogenation reactions?
Reaction Chemistry & Engineering Pub Date: 2019-07-12 DOI: 10.1039/C9RE00032A
Abstract
The hydrogenation of carbonyl compounds over a solid Pd/C catalyst to the corresponding alcohols and of N-heterocycles over a solid Ir@CNT catalyst to the corresponding amines with gaseous hydrogen from water electrolysis without human interaction is presented. This is achieved in three-dimensional parameter space (flow rate, temperature and hydrogen pressure) through an integration of inline FTIR-analysis, a simplex control algorithm and an H-Cube microreactor setup. The simplex method can cope with an initial transient behaviour which is characteristic for heterogeneous catalysis.
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Journal Name：Reaction Chemistry & Engineering
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CAS no.: 89640-58-4
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