Acridine-decorated cyclometallated gold(iii) complexes: synthesis and anti-tumour investigations?
Dalton Transactions Pub Date: 2018-09-03 DOI: 10.1039/C8DT02507J
Abstract
(C^N) and (C^N^C) cyclometalated Au(III) represent a highly promising class of potential anticancer agents. We report here the synthesis of seven new cyclometalated Au(III) complexes with five of them bearing an acridine moiety attached via (N^O) or (N^N) chelates, acyclic amino carbenes (AAC) and N-heterocyclic carbenes (NHC). The antiproliferative properties of the different complexes were evaluated in vitro on a panel of cancer cells including leukaemia, lung and breast cancer cells. We observed a trend between the cytotoxicity and the intracellular gold uptake of some representative compounds of the series. Some of the acridine-decorated complexes were demonstrated to interact with ds-DNA using FRET-melting techniques.
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Journal Name：Dalton Transactions
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CAS no.: 89640-58-4
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