Stereoselective Michael additions on α-aminoacrylates as the key step to an l-Oic analogue bearing a quaternary stereocenter?
Organic & Biomolecular Chemistry Pub Date: 2019-12-16 DOI: 10.1039/C9OB02084E
Abstract
A novel, highly stereoselective route for pharmaceutically relevant octahydroindole-2-carboxylates bearing a quaternary stereocenter has been developed. The key chiral intermediates 3 have been prepared in good yields and enantiomeric excesses up to 98%. A broad substrate range has been tolerated under the reaction conditions.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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