Scalable, efficient total synthesis of (+)-mupirocin H?

Organic Chemistry Frontiers Pub Date: 2013-12-23 DOI: 10.1039/C3QO00038A

Abstract

A scalable, efficient total synthesis of mupirocin H was accomplished in 7 longest linear steps with 39% overall yield. The developed strategy is great progress for the construction of pseudomonic acid analogues and all steps in our strategy could be conducted on a gram scale. The strategy is also suitable for other related molecules.

Graphical abstract: Scalable, efficient total synthesis of (+)-mupirocin H
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