A 4,5-quinolimide-based fluorescent sensor for the turn-on detection of Cd2+ with live-cell imaging?
Organic & Biomolecular Chemistry Pub Date: 2017-02-15 DOI: 10.1039/C7OB00201G
Abstract
A 4,5-quinolimide derivative, BNA, bearing the amide-DPA receptor, was synthesized as a turn-on fluorescent sensor for Cd2+. Under physiological conditions, BNA could distinguish Cd2+ from Zn2+, showing turn-on fluorescence behaviour and an increased fluorescence lifetime. BNA and Cd2+ formed a 1?:?1 stoichiometric complex, and the detection limit was measured to be as low as 11 nM. Furthermore, BNA was utilized for fluorescence imaging of Cd2+ in live cells. To the best of our knowledge, it is the first 4,5-quinolimide-based sensor for the detection of metal ions.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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