Saturated bioisosteres of benzene: where to go next?
Organic & Biomolecular Chemistry Pub Date: 2019-01-10 DOI: 10.1039/C8OB02812E
Abstract
The replacement of para-substituted benzenes with saturated bi- and polycyclic bioisosteres – bicyclo[1.1.1]pentane, bicyclo[2.2.2]octane and cubane, – often increases the potency, selectivity and metabolic stability of bioactive compounds. The currently remaining challenge for chemists, however, is to rationally design, synthesize and validate the saturated bioisosteres for ortho- and meta-substituted benzenes.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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