The synthesis of enantiomerically pure [2.2]paracyclophane derivatives

Organic & Biomolecular Chemistry Pub Date: 2008-03-19 DOI: 10.1039/B800698A

Abstract

[2.2]Paracyclophane is a fascinating molecule that offers great potential in a wide range of chemical disciplines. Currently, the synthesis of the majority of enantiomerically pure [2.2]paracyclophane derivatives is based on the resolution of a small number of starting materials or individual resolution procedures are developed for each new compound. The development of more general routes to these valuable compounds via the resolution of a common intermediate is discussed. Ultimately, it would be preferable to synthesise these valuable compounds without recourse to resolution and ideas for this rewarding goal are postulated.

Graphical abstract: The synthesis of enantiomerically pure [2.2]paracyclophane derivatives
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