Ruthenium-catalyzed direct α-alkylation of amides using alcohols?
Organic & Biomolecular Chemistry Pub Date: 2016-09-09 DOI: 10.1039/C6OB01786J
Abstract
The highly efficient direct α-alkylation of unactivated amides has been accomplished using alcohols in the presence of the Ru-PNN catalyst (0.1 mol%) with a high turnover number. Using this approach, 2-oxindole was directly transformed into C3-alkylated 3-hydroxyindolin-2-one in one step without the use of any oxidant.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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