Solid-state NMR studies of nucleic acid components

RSC Advances Pub Date: 2015-01-09 DOI: 10.1039/C4RA14404J

Abstract

Recent applications of solid-state NMR to the characterisation of nucleic acid systems are reviewed. Developments in NMR methodology and DFT-based first-principles calculations have led to the emergence of “NMR crystallography”, where solid-state NMR provides information on local structure and dynamics that complements information on periodic ordering and overall structure provided by traditional diffraction crystallography. The solid-state NMR is shown to provide direct information on hydrogen-bonding arrangements, metal ion interactions and local molecular dynamics that is difficult to obtain by other techniques, including solution-state NMR.

Graphical abstract: Solid-state NMR studies of nucleic acid components
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