Rhodium-catalyzed triazole-directed C–H bond functionalization of arenes with diazo compounds?
Organic & Biomolecular Chemistry Pub Date: 2018-10-18 DOI: 10.1039/C8OB01673A
Abstract
Heterocyclic compounds bearing 1,2,3-triazole scaffolds have found wide application both in medicinal chemistry and materials science. In this paper, rhodium(III)-catalyzed triazole-directed alkylation reactions of arenes using diazo compounds as the alkylating agents are described. A number of polysubstituted arenes were provided from easily available materials in good yields under mild conditions. The reactions proceed via triazole-directed ortho C–H bond activation and subsequent carbene insertion originating from diazo compounds.
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Journal Name：Organic & Biomolecular Chemistry
research_products
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CAS no.: 89640-58-4
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