Rhodium-catalyzed C–H activation/annulation of amidines with 4-diazoisochroman-3-imines toward isochromeno[3,4-c]isoquinolines?
Organic & Biomolecular Chemistry Pub Date: 2019-08-30 DOI: 10.1039/C9OB01612K
Abstract
A rhodium-catalyzed C–H activation/annulation of amidines with 4-diazoisochroman-3-imines has been established to afford a series of 8-amino-5H-isochromeno[3,4-c]isoquinolines in moderate to good yields with good functional group tolerance. This reaction proceeded in a sequential C–H activation/carbene migration insertion/intramolecular annulation procedure and featured the construction of a C–C and C–N bond in one pot. UV-vis and fluorescence spectral analyses of these highly fused heteroarenes were performed.
![Graphical abstract: Rhodium-catalyzed C–H activation/annulation of amidines with 4-diazoisochroman-3-imines toward isochromeno[3,4-c]isoquinolines](http://scimg.chem960.com/usr/1/C9OB01612K.jpg)
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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