Synthesis of unnatural indolizidines, pyrrolizidine and C-alkyl iminosugars from sugar derived hemiaminals?

RSC Advances Pub Date: 2013-09-25 DOI: 10.1039/C3RA43510E

Abstract

Novel biologically important mono- and bicyclic iminosugars have been synthesized from commercially available sugars following high yielding and short synthetic sequences. These unnatural N-heterocycles have been further tested against several glycosidases and some of them showed good inhibition of the enzymes with moderate selectivity.

Graphical abstract: Synthesis of unnatural indolizidines, pyrrolizidine and C-alkyl iminosugars from sugar derived hemiaminals
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