Synthesis of the C1–C25 southern domain of spirastrellolides B and F?

Organic & Biomolecular Chemistry Pub Date: 2013-08-30 DOI: 10.1039/C3OB41345D

Abstract

Synthesis of the C1–C25 ABC spiroketal ring system of spirastrellolides B and F has been executed. The synthetic strategy relied on radical cyclization, HWE olefination, (BDP)CuH conjugate reduction and spiro acetalization reactions.

Graphical abstract: Synthesis of the C1–C25 southern domain of spirastrellolides B and F
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