Synthesis of symmetrical methylene-bridged imidazoheterocycles using DMSO as methylene source under metal-free conditions?
Organic & Biomolecular Chemistry Pub Date: 2016-05-31 DOI: 10.1039/C6OB00977H
Abstract
A facile H3PO4-promoted bridging methylenation of imidazopyridines or similar heterocycles has been described for the synthesis of symmetrical methylene-bridged imidazoheterocycles, in which DMSO was used as the carbon source. The reaction obtained good yields for most substrates with high C3-regioselectivity. This method also features metal-free, practicability and low cost.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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