Rhodium-catalysed addition of organotrialkoxysilanes to α-substituted acrylic esters

Organic & Biomolecular Chemistry Pub Date: 2006-07-26 DOI: 10.1039/B606977K

Abstract

The cationic rhodium complex [Rh(cod)2][BF4] effectively catalyses the 1,4-addition of organotrialkoxysilanes to α-substituted acrylic esters. The reactions are promoted by heating in an oil-bath or more conveniently in a microwave reactor allowing rapid access to a useful range of functionalised products including 2-alkyl succinates and α-amino acid derivatives.

Graphical abstract: Rhodium-catalysed addition of organotrialkoxysilanes to α-substituted acrylic esters
Recommended Literature