The in situoxidation–Wittig reaction of α-hydroxyketones

Chemical Communications Pub Date: 2002-04-04 DOI: 10.1039/B201513G

Abstract

In situ oxidation–Wittig methodology has been applied to α-hydroxyketones avoiding the problems normally associated with α-ketoaldehydes; the procedure is practically simple, and in many cases gives high yields of the product γ-ketocrotonates; the procedure has also been successfully utilised with ethyl glycolate and glycolaldehyde dimer.

Graphical abstract: The in situ oxidation–Wittig reaction of α-hydroxyketones
Recommended Literature