Ruthenium-catalyzed benzylic substitution of benzyl esters with stabilized carbon nucleophiles?
Chemical Communications Pub Date: 2020-02-10 DOI: 10.1039/C9CC09899B
Abstract
We have accomplished the ruthenium-catalyzed benzylic substitution of benzyl esters with a stabilized carbon nucleophile. A [Cp*RuCl2]2/picolinic acid catalyst system promoted the reaction of 2-naphthylmethyl-2,3,4,5,6-pentafluorobenzoates with a series of stabilized carbon nucleophiles such as malonates, β-ketoesters, and diketones to give the corresponding benzylic alkylation products in moderate to high yields. We proposed a plausible reaction mechanism that could involve a (π-benzyl)ruthenium intermediate.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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