Ruthenium(ii)-catalyzed acyloxylation of the ortho-C–H bond in 2-aroyl-imidazoles with carboxylic acids??
Organic Chemistry Frontiers Pub Date: 2020-08-31 DOI: 10.1039/D0QO00920B
Abstract
The reaction of 2-aroyl-imidazoles with carboxylic acids using [RuCl2(p-cymene)]2 as the catalyst and Ag2CO3 as the oxidant results in ortho-C–H acyloxylation to afford acyloxylation products, in which the imidazole group functions as a directing group. A wide range of functional groups are tolerated in the reaction. The directing group can be easily converted to the corresponding esters under mild conditions.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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