The first Ru(ii)-catalysed asymmetric hydrogen transfer reduction of aromatic ketones in aqueous media

Chemical Communications Pub Date: 2001-09-27 DOI: 10.1039/B106130P

Abstract

The first water-soluble asymmetric hydrogen-transfer ruthenium(II) catalyst system consisting of [Ru(p-cymene)Cl2]2, (S)-proline amide, and sodium formate, which gives high conversion rates with high ee values up to 95.3% and is reusable, has been developed.

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