Singlet oxygen mediated dual C–C and C–N bond cleavage in visible light?
Organic & Biomolecular Chemistry Pub Date: 2020-03-26 DOI: 10.1039/D0OB00563K
Abstract
A tandem cleavage of carbon–carbon and carbon–nitrogen bonds in imidazo[1,2-a]pyridines and imidazo[1,2-a]quinolines is reported in the presence of eosin Y and visible light. The ring opening occurs under ambient conditions through singlet oxygen insertion, bond cleavage and CO2 elimination, and produces N-(pyridin-2-yl) amides and N-(quinolin-2-yl) amides in high yields. The reaction shows good versatility, and does not require strong external oxidants and additives.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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