Retro-biosynthetic construction of corynanthe alkaloid skeletons from rhynchophylline alkaloids?
Organic & Biomolecular Chemistry Pub Date: 2019-08-14 DOI: 10.1039/C9OB01740B
Abstract
Rhynchophylline alkaloids are bio-synthesized from corynanthe alkaloids via an oxidative rearrangement. We demonstrate here that corynanthe alkaloids could be generated from rhynchophylline alkaloids in a retro-biosynthetic manner via a Wagner–Meerwein rearrangement. A series of corynanthe analogues were afforded with good functional group tolerance and satisfactory yields.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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