Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic properties?

Dalton Transactions Pub Date: 2010-08-17 DOI: 10.1039/C0DT00328J

Abstract

Original palladium complexes involving (?)-ephedrine, (?)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified. They have been fully characterized by classical analytical methods and four of them were characterized by X-Ray analysis. In parallel with the experimental work, HF-DFT(B3LYP/PCM) computations were performed to obtain additional structural information. Their antiproliferative properties have been evaluated and some complexes showed small activities especially towards HT29 human cancer cells.

Graphical abstract: Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic properties
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